intracellularly ATP-gated chloride channel activity
http://purl.obolibrary.org/obo/GO_0005260 复制链接

Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. [ http://www.ncbi.nlm.nih.gov/pubmed/9922375 http://www.ncbi.nlm.nih.gov/pubmed/24727426 ]

Synonyms:

CFTR

This is just here as a test because I lose it

Term information

comment
  • This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
has alternative id
  • GO:0005224
has narrow synonym
  • cystic fibrosis transmembrane conductance regulator
has obo namespace
  • molecular_function
has related synonym
  • channel-conductance-controlling ATPase activity
id
  • GO:0005260
term tracker item
  • https://github.com/geneontology/go-ontology/issues/14402