Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.

Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.

Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.

OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate.

The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud.

The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate.

The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate.

Any process in which a protein is transported to, or maintained in, apical regions of the cell.

Any process that decreases the rate, frequency or extent of a chemokine-mediated signaling pathway.

Any process that modulates the rate, frequency or extent of a chemokine-mediated signaling pathway.

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

Any process that increases the rate, frequency or extent of a chemokine-mediated signaling pathway.

The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.

The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

The region that lies just beneath the plasma membrane on the apical edge of a cell.

Any process that modulates the rate, frequency or extent of an interleukin-6-mediated signaling pathway.

Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.

Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.

The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.