A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.

The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.

The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.

Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.

Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.

Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.

Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation.

Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation.

Any process that activates or increases the rate or extent of polarized epithelial cell differentiation.

The lipid bilayer surrounding the rough endoplasmic reticulum.

The lipid bilayer surrounding the smooth endoplasmic reticulum.

A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.

Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.

Any process that activates or increases the rate or extent of B cell proliferation.

Any process that modulates the frequency, rate or extent of B cell proliferation.

OBSOLETE. This term was not defined before being made obsolete.