The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.

The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes.

The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins immediately prior to the initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity.

An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.

A GTPase activity that mediates the joining two lipid bilayers to form a single membrane.

The activity of joining two lipid bilayers to form a single membrane.

The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone).

OBSOLETE. (Was not defined before being made obsolete).

A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules.

A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle.

The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication.

OBSOLETE. (Was not defined before being made obsolete).

Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate.

The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane.

OBSOLETE. (Was not defined before being made obsolete).

The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei.