OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes.

OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set.

OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription.

OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription.

The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol.

The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation.

The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane.

OBSOLETE. The modification of histones by removal of phosphate groups.

OBSOLETE. The modification of histones by addition of phosphate groups.

An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters.

A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.

OBSOLETE. Any complex that mediates dynamic changes in eukaryotic chromatin.

OBSOLETE. Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.

OBSOLETE. (Was not defined before being made obsolete).

OBSOLETE. The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups.

An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.

A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.

The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.